pinboard January 12, 2022

  • Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants – PubMed
    Abstract
    As a complement to vaccines, small-molecule therapeutic agents are needed to treat or prevent infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, which cause COVID-19. Affinity selection-mass spectrometry was used for the discovery of botanical ligands to the SARS-CoV-2 spike protein. Cannabinoid acids from hemp (Cannabis sativa) were found to be allosteric as well as orthosteric ligands with micromolar affinity for the spike protein. In follow-up virus neutralization assays, cannabigerolic acid and cannabidiolic acid prevented infection of human epithelial cells by a pseudovirus expressing the SARS-CoV-2 spike protein and prevented entry of live SARS-CoV-2 into cells. Importantly, cannabigerolic acid and cannabidiolic acid were equally effective against the SARS-CoV-2 alpha variant B.1.1.7 and the beta variant B.1.351. Orally bioavailable and with a long history of safe human use, these cannabinoids, isolated or in hemp extracts, have the potential to prevent as well as treat infection by SARS-CoV-2.
  • Without Code for DeepMind’s Protein AI, This Lab Wrote Its Own | WIRED
    The Google subsidiary solved a fundamental problem in biology but didn’t promptly share its solution. So a University of Washington team tried to re-create it.
  • 3 Amazing Obsidian Plugins [[DataView]], [[Outliner]], & [[Templater]] – YouTube
  • Predictions of the SARS-CoV-2 Omicron Variant (B.1.1.529) Spike Protein Receptor-Binding Domain Structure and Neutralizing Antibody Interactions | bioRxiv
    The genome of the SARS-CoV-2 Omicron variant (B.1.1.529) was released on November 22, 2021, which has caused a flurry of media attention due the large number of mutations it contains. These raw data have spurred questions around vaccine efficacy. Given that neither the structural information nor the experimentally-derived antibody interaction of this variant are available, we have turned to predictive computational methods to model the mutated structure of the spike protein’s receptor binding domain and posit potential changes to vaccine efficacy. In this study, we predict some structural changes in the receptor-binding domain that may reduce antibody interaction without completely evading existing neutralizing antibodies (and therefore current vaccines).
  • Presidential Greeting Request | The White House
    Presidential Greeting Request
  • Meet Mr Trash Wheel – and the other new devices that eat river plastic
    From ‘bubble barriers’ to floating drones, a host of new projects aim to stop plastic pollution before it ever reaches the ocean

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