• Statement by President Biden on Senate Passage of the Inflation Reduction Act – The White House
• Dawn Platinum Powerwash Dish Spray, Dishwashing Soap – Fresh Scent – 16oz : Target
• Republicans block cap on insulin costs for millions of patients
• The Senate just passed one of the biggest bills to fight climate change, ever — Vox
  What’s in the "game changer" climate bill nobody saw coming.
• Senate Democrats pass sweeping healthcare, tax and climate bill — Los Angeles Times
  Senate Democrats united behind the Inflation Reduction Act to address healthcare, taxes and climate change and to let Medicare negotiate drug prices.
• History’s Greatest Obstacle to Climate Progress Has Finally Fallen
  Democrats in the Senate passed a bill that would, for the first time ever, use Congress’s power to push the U.S. to decarbonize.
• The Secret History of Family Separation – The Atlantic

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• It’s Time to Stop Living the American Scam
  Tim Kreider
• Terminal Lucidity – The Loaf, with Tim Kreider
  Contemplating Our Converging Crises

  Tim Kreider

• Study identifies broad-spectrum antibody that neutralizes SARS-CoV-2 variants of concern | News-Medical
• Persistent viral infections within hosts cause post-acute sequelae of COVID-19, research shows
• State Legislatures Are Torching Democracy
  Jane Mayer
  Even in moderate places like Ohio, gerrymandering has let unchecked Republicans pass extremist laws that could never make it through Congress.

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• Watch "Maria Joao Pires expecting another Mozart concerto during a lunchconcert in Amsterdam" on YouTube
• Two Ways To Think About Nothing : Krulwich Wonders… : NPR
• Against Netflix
• The Abandoned Eastalco Alcoa Works (Frederick, MD)
  The Eastalco Alcoa works was a fascinating industrial wonderland, idled then abandoned and torn down shortly after. This is what it looked like before they demolished it. By Matthew Christopher’s Abandoned America.
• Antigen and Molecular Tests for COVID-19
  The diagnostic testing field for COVID-19 is rapidly evolving, with many tests focused on diagnosing patients with active viral infections.
• Molecular Tests | Types of COVID-19 Tests
  Molecular tests amplify bits of viral RNA so that viral infection can be detected using a specialized test. These tests also are referred to as nucleic acid amplification tests (NAAT).
• Larry Brilliant Says Covid Rapid Tests Are Bad for Public Health — WIRED
  The epidemiologist who helped quash smallpox talks about what we’re doing wrong on monkeypox, vaccines, and antigen tests.
• Cutting-edge window heat pumps are coming to New York public housing
  Window heat pumps aren’t just good for the climate. They could begin to remedy long-standing environmental injustices.
• Broadway Baby: The Astonishing Autobiography of Mary Rodgers
  The daughter of Richard Rodgers, confidante of Stephen Sondheim and composer of “Once Upon a Mattress” holds nothing back in “Shy.”
• Notable Sandwiches #32: Cheese & Pickle
  Thank God for comfort food.

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• Long COVID comes in three forms: study  – The Hill
• Wyze Handheld Vacuum | Portable Vacuum Cleaner for Home and Car
• [no title]
• The Mini Sampler Set – Kate McLeod
• Boxers With Pockets | House Shorts | Jambys | Flamingo/Taffy
• A ‘Reversible’ Form of Death? Scientists Revive Cells in Dead Pigs’ Organs.
  Researchers who previously revived some brain cells in dead pigs succeeded in repeating the process in more organs.

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• The Kansas victory shows that Democrats can fight for abortion rights and win | Moira Donegan
• The Origins of Covid-19 Are More Complicated Than Once Thought — WIRED
  Scientists used painstaking research, genomics, and clever statistics to definitively track two distinct strains of the virus back to a wet market in Wuhan.
• Seattle approves permanent 15% fee cap on food delivery companies, with key compromise – GeekWire
• Seawalls ease property owners’ fears of erosion – but not for their neighbors | Milwaukee | The Guardian
  After Concordia University Wisconsin built a 2,700ft rock wall to protect its beach and bluff, neighbors saw their own beaches begin to wash away
• 35,000 code repos not hacked—but clones flood GitHub to serve malware
• BigQuery Tutorial | MIMIC

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• Understanding Electronic Health Records with BigQuery ML
  Understanding Electronic Health Records with BigQuery ML
  This tutorial introduces BigQuery ML (BQML) in the context of working with the MIMIC3 dataset.

  BigQuery ML adds only a few statements to standard SQL. These statements automate the creation and evaluation of statistical models on BigQuery datasets. BigQuery ML has several advantages over older machine learning tools and workflows. Some highlights are BQML’s high performance on massive datasets, support for HIPAA compliance, and ease of use. BQML automatically implements state of the art best practices in machine learning for your dataset.

  MIMIC3 is a 10-year database of health records from the intensive care unit of Beth Israel Deaconess Medical Center in Boston. It’s full of insights that are just begging to be uncovered.

• MIMIC — Medical Information Mart for Intensive Care
  Freely available medical data for research.
• MLOps: Right Problem, Wrong Solution | Aqueduct Blog
• [The Washington Post] Kansans resoundingly reject amendment aimed at restricting abortion rights
• Plane Passenger Risk of Contracting COVID May Be Higher, MIT Research
• Study indicates that cross-reactive immunity against SARS-CoV-2 N protein was present in Africa prior to the pandemic
• Why Do Rich People Love Quiet? – The Atlantic
  The sound of gentrification is silence.
• University of West Georgia educator charged with murder in death of incoming student
• I Care A Lot. On domestic labor, “bitter” housewives… | by Jude Ellison S. Doyle | Aug, 2022 | Medium

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• One last trip: Gabriella Walsh’s decision to die — and celebrate life — on her own terms – Los Angeles Times
• The Prosecution of Russian War Crimes in Ukraine
  Twenty-five thousand cases have been identified thus far—what does justice look like for the victims of Russia’s atrocities?

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• Hidden Menace: Massive methane leaks speed up climate change
  LENORAH, Texas (AP) — To the naked eye, the Mako Compressor Station outside the dusty West Texas crossroads of Lenorah appears unremarkable, similar to tens of thousands of oil and gas operations scattered throughout the oil-rich Permian Basin.

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• writing one sentence per line | Derek Sivers

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• The key to universal Covid-19 vaccines lies in your bones
• Secret Service’s ‘ludicrous’ deletion of Jan. 6 phone data baffles experts
• Top predators as biodiversity indicators: A meta?analysis
  tl;dr: The existence of top predators is a key sign of a healthy ecosystem.
• Hospices Have Become Big Business for Private Equity Firms, Raising Concerns About End-of-Life Care
  tl;dr: Private equity’s expanding death-grip on U.S. hospices
• K2 Sherpa Train Hauls 145 People To The Summit In One Day
  Has K2 jumped the shark?
• Effects of total knee arthroplasty on skeletal muscle structure and function at the cellular, organellar and molecular levels | Journal of Applied Physiology
  Total knee arthroplasty (TKA) is an important treatment option for knee osteoarthritis (OA) that improves self-reported pain and physical function, but objectively measured physical function typically remains reduced for years after surgery due, in part, to precipitous reductions in lower extremity neuromuscular function early after surgery. The present study examined intrinsic skeletal muscle adaptations during the first 5 weeks post-TKA to identify skeletal muscle attributes that may contribute to functional disability. Patients with advanced stage knee OA were evaluated prior to TKA and 5 weeks after surgery. Biopsies of the vastus lateralis were performed to assess muscle fiber size, contractility, and mitochondrial content, along with assessments of whole muscle size and function. TKA was accompanied by marked reductions in whole muscle size and strength. At the fiber (ie, cellular) level, TKA caused profound muscle atrophy that was ~2-fold higher than that observed at the whole muscle level. TKA markedly reduced muscle fiber force production, contractile velocity, and power production, with force deficits persisting in MHC II fibers after expression relative to fiber size. Molecular level assessments suggest reduced strongly bound myosin-actin cross-bridges and myofilament lattice stiffness as a mechanism underlying reduced force per unit fiber size. Finally, marked reductions in mitochondrial content were apparent and more prominent in the sub-sarcolemmal compartment. Our study represents the most comprehensive evaluation of skeletal muscle cellular level adaptations to TKA and uncovers novel effects of TKA on muscle fiber size and intrinsic contractility early after surgery that may contribute to functional disability.

  tl;dr: Knee replacement is associated with profound muscle atrophy. /cc @hjluks

  Effects of total knee arthroplasty on skeletal muscle structure and function at the cellular, organellar and molecular levels

• How can you put a bash array into a wdl variable? – Bioinformatics Stack Exchange
• How to get a job in climate tech | Sifted

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