Entries from February 2022 ↓
February 28th, 2022 — Uncategorized
- Genetic associations of protein-coding variants in human disease | Nature
Genome-wide association studies (GWAS) have identified thousands of genetic
variants linked to the risk of human disease. However, GWAS have so far
remained largely underpowered in relation to identifying associations in
the rare and low-frequency allelic spectrum and have lacked the resolution
to trace causal mechanisms to underlying genes1. Here we combined
whole-exome sequencing in 392,814 UK Biobank participants with imputed
genotypes from 260,405 FinnGen participants (653,219 total individuals) to
conduct association meta-analyses for 744 disease endpoints across the
protein-coding allelic frequency spectrum, bridging the gap between common
and rare variant studies. We identified 975 associations, with more than
one-third being previously unreported. We demonstrate population-level
relevance for mutations previously ascribed to causing single-gene
disorders, map GWAS associations to likely causal genes, explain disease
mechanisms, and systematically relate disease associations to levels of 117
biomarkers and clinical-stage drug targets. Combining sequencing and
genotyping in two population biobanks enabled us to benefit from increased
power to detect and explain disease associations, validate findings through
replication and propose medical actionability for rare genetic variants.
Our study provides a compendium of protein-coding variant associations for future insights into disease biology and drug discovery.
- U.N. climate panel issues “bleakest warning yet,” says window to secure a livable future is closing — The Guardian
Report says human actions are causing dangerous disruption, and window to secure a liveable future is closing
- (400) https://twitter.com/CelesteHeadlee/status/1497989763894239242/photo/1
RT @CelesteHeadlee: This photo is my great-grandmother, Bessie Tartakovsky Arvey, born in 1883 in Zhitomir, Ukraine. Her family fled to the US during the Russian pogroms. (They were Jewish). Her daughter married composer William Grant Still (2nd photo)
- Heat Pumps for Peace and Freedom – by Bill McKibben
- Russia-Ukraine War: Info and ways to help
Digest powered by RSS Digest
February 27th, 2022 — Uncategorized
Digest powered by RSS Digest
February 26th, 2022 — Uncategorized
Digest powered by RSS Digest
February 25th, 2022 — Uncategorized
Digest powered by RSS Digest
February 24th, 2022 — Uncategorized
Digest powered by RSS Digest
February 23rd, 2022 — Uncategorized
- Serbian scientists install an urban photo-bioreactor to capture CO2 and produce O2 just like trees – Yanko Design
- A psychoanalytic reading of social media and the death drive – Max Read – Bookforum Magazine
- Altruistic Australian Magpies Peck Off Each Other's Tracking Devices, Foiling Researchers | IFLScience
- Not a fan of America in the Darkest Timeline? Blame Florida and the year 2000
When Trump hit Pat Buchanan from the left (in this paper!), how the age of Twitter could have helped Gore and other gems from the author of ‘The Year That Broke America.’
- Where Oaken Hearts Do Gather |
- gulf | Etymology, origin and meaning of gulf by etymonline
GULF Meaning: "profound depth," from Old French golf "a gulf, whirlpool," from Italian golfo "a gulf, a bay," from… See definitions of gulf.
- Review | In Joel Agee’s wondrous ‘The Stone World’ a boy tries to make sense of life
The range and caliber of Joel Agee’s work proves he’s much more than the son of the late, Pulitzer-winning James Agee.
- What to Do When a Loved One Is Severely Depressed (Published 2018)
There are no easy answers for helping someone struggling with depression, especially if you’ve already tried and tried. Here are some tips from experts.
- Big Tech Makes a Big Bet: Offices Are Still the Future
Even as they allow some employees to change how often they come into the office, tech companies are rapidly buying and leasing properties around the country.
- GoogleCloudPlatform/vertex-ai-spark-ml-serving
- Exclusive: Austrian Programmer And Ex Crypto CEO Likely Stole $11 Billion Of Ether
Digest powered by RSS Digest
February 22nd, 2022 — Uncategorized
Digest powered by RSS Digest
February 21st, 2022 — Uncategorized
Digest powered by RSS Digest
February 20th, 2022 — Uncategorized
Digest powered by RSS Digest
February 19th, 2022 — Uncategorized
- Getaway house
Nestled in Mount Vernon, WA, our brand new Outpost, Getaway Skagit Valley is open for your escape from Seattle.
- A Man in a Cafe Asked Julie Otsuka What She Was Reading. They Dated for Two Years.
“An everyday pickup line, but it worked,” says the novelist, whose new book is “The Swimmers.” “I haven’t been in touch with him since, but I return to ‘The Lover’ every now and again, and never fail to fall under its spell.”
- Guns, Race, Abortion: Jennifer Haigh’s New Novel Humanizes Hot-Button Topics
Haigh’s latest book, “Mercy Street,” is set at a women’s clinic in Boston where the threat of violence is pervasive.
- The Seven Habits That Lead to Happiness in Old Age – The Atlantic
- (400) https://twitter.com/nycsouthpaw/status/1494758078851526662/photo/1
RT @nycsouthpaw: The Archives confirms last week’s stories:
– "NARA has identified items marked as classified national security within the [Mar-a-Lago] boxes."
– "Because NARA identified classified information in the boxes, NARA staff has been in communication with the Dept of Justice."
- Koch Machine Pressing Supreme Court To Crush EPA
RT @JaneMayerNYer: Behind what looks like many groups, one gargantuan fossil fuel fortune: Koch Machine Pressing Supreme Court To Crush EPA
- Fahrenheit Notebooks – Fahrenheit Press
Bookish Weirdo
- The Pandemic Isn’t Over for Immunocompromised People – The Atlantic
What does society owe immunocompromised people?
Digest powered by RSS Digest