Entries from February 2022 ↓

• Genetic associations of protein-coding variants in human disease | Nature
  Genome-wide association studies (GWAS) have identified thousands of genetic
  variants linked to the risk of human disease. However, GWAS have so far
  remained largely underpowered in relation to identifying associations in
  the rare and low-frequency allelic spectrum and have lacked the resolution
  to trace causal mechanisms to underlying genes1. Here we combined
  whole-exome sequencing in 392,814 UK Biobank participants with imputed
  genotypes from 260,405 FinnGen participants (653,219 total individuals) to
  conduct association meta-analyses for 744 disease endpoints across the
  protein-coding allelic frequency spectrum, bridging the gap between common
  and rare variant studies. We identified 975 associations, with more than
  one-third being previously unreported. We demonstrate population-level
  relevance for mutations previously ascribed to causing single-gene
  disorders, map GWAS associations to likely causal genes, explain disease
  mechanisms, and systematically relate disease associations to levels of 117
  biomarkers and clinical-stage drug targets. Combining sequencing and
  genotyping in two population biobanks enabled us to benefit from increased
  power to detect and explain disease associations, validate findings through
  replication and propose medical actionability for rare genetic variants.
  Our study provides a compendium of protein-coding variant associations for future insights into disease biology and drug discovery.
• U.N. climate panel issues “bleakest warning yet,” says window to secure a livable future is closing — The Guardian
  Report says human actions are causing dangerous disruption, and window to secure a liveable future is closing
• (400) https://twitter.com/CelesteHeadlee/status/1497989763894239242/photo/1
  RT @CelesteHeadlee: This photo is my great-grandmother, Bessie Tartakovsky Arvey, born in 1883 in Zhitomir, Ukraine. Her family fled to the US during the Russian pogroms. (They were Jewish). Her daughter married composer William Grant Still (2nd photo)
• Heat Pumps for Peace and Freedom – by Bill McKibben
• Russia-Ukraine War: Info and ways to help

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• seattle free stuff – craigslist
• The Road to Pleasure is Paved with Precision Medicine – NEO.LIFE
  An experimental drug that addresses anhedonia could increase the brain’s capacity to experience pleasure and herald a new era of precision medicine in psychiatry.

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• Dorayaki, galettes and blintzes: Yotam Ottolenghi’s pancake recipes from around the world
• Perspective | How a little-discussed revision of climate science could help avert doom
  We can reduce global temperatures faster than we once thought â?? if we act now.
• The Best Climate Science You've Never Heard Of
• parmesan broth with kale and white beans – smitten kitchen
• Miramar Wide Leg | Apparel Jeans | rag & bone
  Trompe L’oeil Cotton Pant
• Liverpool Los Angeles | Denim & Casual Sportswear – LIVERPOOL LOS ANGELES
• Grief Belongs in Social Movements. Can We Embrace It?
• Coconut Oat Chilli Crisp
• It's Putin’s tale of two cities – London for his oligarchs, Kyiv for his bombs | Marina Hyde
  Our capital pulls its punches when it comes to penalising Russiaâ??s richest, but Putin shows no such mercy to Ukraine, says Guardian columnist Marina Hyde
• Opinion | Laundered Money Could Be Putin’s Achilles’ Heel
  We can and should freeze oligarchs’ overseas assets.

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• AAAI2022: A Demonstration of Compositional, Hierarchical Interactive Task Learning
  Soar
• ‘Frozen in Place’ Fossils Reveal Dinosaur-Killing Asteroid Struck in Spring
• The Crushing Loss of Hope in Ukraine | The New Yorker
  RT @mashagessen: In which the heart breaks. The Crushing Loss of Hope in Ukraine via @NewYorker

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• The Story of Gordon Parks's 'Colored Entrance' Photo: Shirley and Allie Lee Causey
• War in Ukraine: free to read
• Do you need an 'armpit detox?' Myths about aluminum and deodorant, explained — USA TODAY
  One of the recent trends that caught my eye is the “armpit detox” with people looking to move from traditional antiperspirant to “natural deodorant.”
• Everyone puts hydrogen peroxide on their wounds. They really shouldn't. — USA TODAY
  While hydrogen peroxide does have known antiseptic properties, it may do more harm than good when it comes to wound care.
• Russia invasion of Ukraine ignites European security crisis — Bloomberg
  Russia began a full-scale invasion of its neighbor Ukraine after President Vladimir Putin vowed to “demilitarize” the country of more than 40 million people, triggering one of the worst security crises in Europe since World War II.
• Video of Thay’s funeral and cremation
  Thay’s funeral on Saturday, 29th January 2022, was one of the biggest Hu?, Vietnam has seen for decades. Thousands came out to join the procession, in a deep expression of love and respect for a…
• Dwarf Factory Terrarium Resin Artisan Keycap – Dom | Drop
• (400) https://twitter.com/AITA_online/status/1494811862185259012
  RT @Nicklezard: Best @AITA ever. Also contains the immortal line "the Brits have emerged as factional leaders".
• Google Cloud Developer Cheat Sheet
  architecture design tool

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• Serbian scientists install an urban photo-bioreactor to capture CO2 and produce O2 just like trees – Yanko Design
• A psychoanalytic reading of social media and the death drive – Max Read – Bookforum Magazine
• Altruistic Australian Magpies Peck Off Each Other's Tracking Devices, Foiling Researchers | IFLScience
• Not a fan of America in the Darkest Timeline? Blame Florida and the year 2000
  When Trump hit Pat Buchanan from the left (in this paper!), how the age of Twitter could have helped Gore and other gems from the author of ‘The Year That Broke America.’
• Where Oaken Hearts Do Gather |
• gulf | Etymology, origin and meaning of gulf by etymonline
  GULF Meaning: "profound depth," from Old French golf "a gulf, whirlpool," from Italian golfo "a gulf, a bay," from… See definitions of gulf.
• Review | In Joel Agee’s wondrous ‘The Stone World’ a boy tries to make sense of life
  The range and caliber of Joel Agee’s work proves he’s much more than the son of the late, Pulitzer-winning James Agee.
• What to Do When a Loved One Is Severely Depressed (Published 2018)
  There are no easy answers for helping someone struggling with depression, especially if you’ve already tried and tried. Here are some tips from experts.
• Big Tech Makes a Big Bet: Offices Are Still the Future
  Even as they allow some employees to change how often they come into the office, tech companies are rapidly buying and leasing properties around the country.
• GoogleCloudPlatform/vertex-ai-spark-ml-serving
• Exclusive: Austrian Programmer And Ex Crypto CEO Likely Stole $11 Billion Of Ether

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• How They Did It: Sandy Hook Families Gain Long-Awaited Legal Wins
  After early defeats in Congress, relatives of those lost in the 2012 shooting fought on, besting a renowned gun maker and an infamous conspiracy theorist.
• Venus and Serena Williams on Their Own Terms
• Francis Ford Coppola’s $100 Million Bet | GQ
• High-Waisted PowerSoft 7/8-Length Joggers for Women | Old Navy
• Stanford University uses AI computing to cut DNA sequencing down to five hours | ZDNet
• The Pringle as Technology – The Atlantic
• How do you help a grieving friend?
  How do you respond to pain? When we talk about the skills needed to support a grieving friend, we’re not just talking about grief related to death.
• A Month of Paid Leave Was Transformative for My Workplace | Teen Vogue

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• 80-unit residential building for low-income and unhoused Indigenous people opens in Seattle
• Crypto Scammers’ New Target: Dating Apps
  “Everything was a lie,” said one woman lured into a recent scam.

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• Who Is Behind QAnon? Linguistic Detectives Find Fingerprints
  Using machine learning, separate teams of computer scientists identified the same two men as likely authors of messages that fueled the viral movement.
• An Oral History of the ‘Mamma Mia: Here We Go Again’ Ending

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• Getaway house
  Nestled in Mount Vernon, WA, our brand new Outpost, Getaway Skagit Valley is open for your escape from Seattle.
• A Man in a Cafe Asked Julie Otsuka What She Was Reading. They Dated for Two Years.
  “An everyday pickup line, but it worked,” says the novelist, whose new book is “The Swimmers.” “I haven’t been in touch with him since, but I return to ‘The Lover’ every now and again, and never fail to fall under its spell.”
• Guns, Race, Abortion: Jennifer Haigh’s New Novel Humanizes Hot-Button Topics
  Haigh’s latest book, “Mercy Street,” is set at a women’s clinic in Boston where the threat of violence is pervasive.
• The Seven Habits That Lead to Happiness in Old Age – The Atlantic
• (400) https://twitter.com/nycsouthpaw/status/1494758078851526662/photo/1
  RT @nycsouthpaw: The Archives confirms last week’s stories:

  – "NARA has identified items marked as classified national security within the [Mar-a-Lago] boxes."

  – "Because NARA identified classified information in the boxes, NARA staff has been in communication with the Dept of Justice."

• Koch Machine Pressing Supreme Court To Crush EPA
  RT @JaneMayerNYer: Behind what looks like many groups, one gargantuan fossil fuel fortune: Koch Machine Pressing Supreme Court To Crush EPA
• Fahrenheit Notebooks – Fahrenheit Press
  Bookish Weirdo
• The Pandemic Isn’t Over for Immunocompromised People – The Atlantic
  What does society owe immunocompromised people?

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